She lives and works between Milan and São Paulo. 
She is interested in exploring how power structures can be subtle, insidious, and imperceptible, as well as brutal and invasive, ranging from historical dynamics of colonization to technological control to personal-level dynamics.

Several key themes recur in the works of Debora Hirsch, such as contemporary anthropology, unnoticed interrelationships, hidden realities, the influence of media and technology on culture and society, defining the multidisciplinary nature of her artistic practice. While her work is often conceptual and appropriative – gathering images from archives, old books, the digital world, art, and a variety of media – she constructs her own imagery and perspective through a metaphysical conception of art.

Her visual language deliberately invites viewers to investigate and reconsider their actions and existence. Her preferred method for producing drawings, paintings, videos, websites, installations, and objects is to progress through associations and deductions. Debora Hirsch's works are often elaborate snapshots of an ongoing investigation that includes theories, conjectures, reinterpretations of signs on seemingly irrelevant realities, hidden interconnections, and similarities between distant worlds and times.

Her works are part of several public and private collections, including the MOCAK Museum Of Contemporary Art in Krakow (PL), MuBe Museu Brasileiro da Escultura e Ecologia (BR), Casa Testori (IT), Fondation Francès (FR), Benetton (IT), Arte Mondadori (IT), Collezione Ernesto Esposito (IT), Collezione AGI Verona (IT), Collezione Banca Monte dei Paschi (IT), Museo Premio Suzzara (IT), Collezione VR Vittorio Rappa (IT), Fondazione Rivoli2 in Milan (IT), Hutchinson Modern in NY (USA), Museo BoCs (IT).