She lives and works in Rome. She studied Painting at RUFA - Rome University of Fine Arts, graduating in 2019, and conducted her thesis research spending time at KASK in Ghent, Belgium.

In 2017, she was selected for the Mediterranea 18 Young Artists Biennale, and the following year, she became a part of Spazio In Situ, a space managed by artists and a shared co-working space located in the Roman suburb of Tor Bella Monaca.

Federica Di Pietrantonio's artistic research focuses on relationships and processes that arise through simulated/virtual realities, social platforms, and video games. Video games delineate the boundaries of the artistic process, where the standardization of personality and the illusion of our individuality simultaneously take place in free modes of relating and interacting.

Virtual experience is now a confirmed constructor of our memory, playing an active role, albeit partly driven by melancholy, in the individual/collective construction of the present. The body is a recognition device capable of identifying oneself and virtual alter egos; a device no longer definitively defined but involved in a continuous process of creation and destruction. Assuming a correspondence between avatar and alter ego, absurdly the avatar is the ego itself.

The sublime act of finding oneself in others appears as a closed cyclical structure, without hope. Her work often oscillates between perceived reality and the fictitious quality of virtual devices, persistently trying to break the fragile certainties offered by our contemporary society. Although illusion is a paradise in which to wander, the experience brutally confronts reality. A predictable crash. Her freedom ends up being offered to the viewer.

Since 2018, her collaboration with Andrea Frosolini has given birth to ISIT (an independent editorial project and curatorial platform) and the artistic duo AFFDP. Di Pietrantonio has exhibited in private and institutional spaces, including Manifattura Tabacchi (Florence), Las Palmas (Lisbon), Una Vetrina (Rome), Temple University Gallery (Rome), The Gallery Apart (Rome), Spazio In Situ (Rome), TILT (Renens, Switzerland), GAM – Galleria d'Arte Moderna di Roma Capitale (Rome), Virginia Bianchi Gallery (online), Adiacenze (Bologna, Italy), ADI Design Museum (Milan), FMAV – Fondazione Modena Arti Visive (Modena, Italy).

Among her solo exhibitions, notable ones include "Ogni notte cerco di trovare la luce ma a volte fa troppo freddo" at the Fondazione smART – Polo per l’Arte in Rome (2022), the duo exhibition with Andrea Frosolini "Dumpster Love Yourself" at Adiacenze in Bologna, "Lost in Myst Project" in Celleno (VT) (2021), and "My Life as Yours" at The Gallery Apart in Rome (2020).

In 2020, she won the special Emerging Award from the Fondazione Cultura e Arte during the 13th edition of the Talent Prize promoted by Inside Art magazine. She was also among the finalists in the subsequent editions of 2021 and 2022.

In 2021, she was selected by NAM – Not a Museum for the Superblast residency at Manifattura Tabacchi in Florence.

In 2022, she participated in VRAL #49 as part of the Milan Machinima Festival and was invited to present her work at MEET – Centro di Cultura Digitale in Milan during the international conference The New Atlas of Digital Art.